Membrane properties of rat magnocellular neuroendocrine cells in vivo |
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Authors: | C.W. Bourque L.P. Renaud |
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Affiliation: | aCenter for Research in Neuroscience, Montreal General Hospital, Montreal, Que., Canada |
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Abstract: | Membrane properties of rat magnocellular neuroendocrine cells (MNCs) were examined during intracellular recordings in vivo. Current-clamp experiments revealed sustained outward rectification positive to −55 mV and transient outward rectification of depolarizing responses elicited from negative holding potentials. Trains of impulses were associated with a progressive increase of spike duration. Such features, which were not observed in neighboring non-neuroendocrine cells, are similar to those of MNCs in slices or explants of rat hypothalalus. In contrast, however, cells recorded in vivo were characterized by intense synaptic inhibition and a lower specific impedance than commonly observed from MNCs impaled in vitro. |
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Keywords: | Supraoptic nucleus Intracellular recording Neurosecretory cell Rat |
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