| 西咪替丁对戊巴比妥睡眠时间的影响 |
| |
| 摘 要： | 腹腔内一次注射476μmol/kg西咪替丁,雌雄小鼠和大鼠的戊巴比妥睡眠时间分别延长102%、127%和43%、119%(P<0.01);等摩尔雷尼替丁对上述动物PST无明显影响。多次poCD476μmol/kg,雄性大鼠PST延长81%(P<0.01),相同条件下RD对PST亦无明显影响。并发现多次poCD后,其戊巴比妥血浓度与PST呈正相关。并初步探讨了CD延长PST的机理。
|
| 关 键 词： | 西咪替丁 雷尼替丁 戊巴比妥钠 睡眠时间 血浓度 |
THE EFFECTS OF CIMETIDINE & RANITIDINE ON PENTO-BARBITAL SLEEPING TIMES IN RATS & MICE |
| |
| Abstract: | The pentobarbital sleeping times ( PST ) in rats and mice pretreated with ranitidine acutely or chronically do not differ significantly from the control groups. But the PST pretreated with cimetidine acutely and chronically both do prolong significantly in rats and mice. The blood pentobarbital concentration in the male rats pretreated with cimetidine chronically is significantly higher than the ranitidine and control groups. Close relationship between the PST and the blood pentobarbital concentration has been observed. |
| |
| Keywords: | Ranitiidine Cimetidine Pentobarbital Sleeping time Blood concentration |
|
