儿童紫癜性肾炎体液免疫状态分析

目的探讨紫癜性肾炎患儿的体液免疫状态及其发病机制。方法对39例紫癜性肾炎患儿及30例健康儿童的血清采用全自动生化分析仪进行IgG、IgA、IgM、C3、C4检测；紫癜性肾炎患儿另行肾脏病理检查与诊断。比较紫癜性肾炎患儿与健康儿童血清免疫球蛋白及补体的差异性．以及紫癜性肾炎患儿肾脏损害与免疫紊乱的相关性。结果紫癜性肾炎患儿血清IgG、IgA水平明显高于健康儿童．而IgM、C3、C4低于健康儿童（P〈0．05或0．01）。紫癜性肾炎患儿病理级别间血清免疫球蛋白及补体差异均无显著性（P〉0．05）。结论紫癜性肾炎患儿存在严重的免疫功能紊乱．肾脏损害程度似与免疫紊乱无育接相关性。

Analyses of humoral immunity state in children with the Henoch-Schonlein purpura nephritis

Objective To explore the humoral immunity state and pathogenesis in children with Henoch-Schonlein purpura nephritis (HSPN). Methods Serum IgG, IgA, IgM, C3 and C4 levels were detected in 39 children with HSPN and 30 healthy ones using full-automatic biochemistry analyzer. Results Serum IgG and IgA levels of patients were significantly higher, while IgM, C3 and C4 lower compared to controls(P<0.05 or 0.01). There were no significant differences in immunoglobulin and complements as for pathological grades(P>0.05).Conclusion There was severe disturbance of immunologic function in children with HSPN, and degrees of renal damage may not be directly related to immunologic disturbance.