| 三氧化二砷诱导多药耐药白血病细胞K562-n/VCR凋亡 |
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| 引用本文： | 许晓巍,许小平,陈少谊,易克,陈莉,吕书晴,贾新颜. 三氧化二砷诱导多药耐药白血病细胞K562-n/VCR凋亡[J]. 白血病．淋巴瘤, 2005, 14(1): 4-6 |
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| 作者姓名： | 许晓巍 许小平 陈少谊 易克 陈莉 吕书晴 贾新颜 |
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| 作者单位： | 200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科;200433,上海,第二军医大学附属长海医院血液科 |
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| 基金项目： | 国家自然科学基金，39770330， |
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| 摘 要： | 目的 研究三氧化二砷(AS2O3)对裸鼠高成瘤性慢性粒细胞白血病(CML)急变细胞系K562-n及其表达mdr-1的多药耐药细胞系K562-n／VCR诱导凋亡作用的差异。方法 采用WST法、细胞形态学、流式细胞术等多参数分析。结果 AS2O3对K562-n及K562-n／VCR的抑制作用无显著性差异。AS2O3对K562-n及K562-n／VCR细胞的凋亡诱导作用呈作用时间和浓度依赖关系。结论 AS2O3对表达mdr—1的CML急变期细胞系K562-n／VCR具有抑制生长及较明显的诱导凋亡作用。
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| 关 键 词： | 三氧化二砷 凋亡 白血病 多药耐药 |
| 文章编号： | 1009-9921(2005)01-0004-03 |
| 修稿时间： | 2004-09-01 |
Apoptosis on multi-drug resistant leukemia cell line K562-n/VCR induced by arsenic trioxide |
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| XU Xiao-wei,XU Xiao-ping,CHEN Shao-yi,YI Ke,CHEN Li,Lü Shu-qing,JIA Xin-yan. Apoptosis on multi-drug resistant leukemia cell line K562-n/VCR induced by arsenic trioxide[J]. Journal of Leukemia & Lymphoma, 2005, 14(1): 4-6 |
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| Authors: | XU Xiao-wei XU Xiao-ping CHEN Shao-yi YI Ke CHEN Li Lü Shu-qing JIA Xin-yan |
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| Abstract: | Objective To investigate the efficacy of arsenic trioxide (As2O3) on K562- n and K562- n/VCR. Methods The apoptosis of the two cell lines induced by As2O3 solution of different concentrations were studied with WST, cell morphology and flow cytometry. Results It was found that there was no significant different of IC50 between K562- n and K562- n/VCR. As2O3 could induce the apoptosis of K562- n and K562- n/VCR cell lines, which dependent on its concentration and time in vitro. Conclusions As2O3 had a pronounced effect on K562- n/VCR cell line expressing mdr- 1 gene. |
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| Keywords: | Arsenic trioxide Apoptosis Leukaemia Multi- drug resistance |
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