In Vitro Activity and β-Lactamase Stability of Cefazaflur Compared with Those of β-Lactamase-Stable Cephalosporins |
| |
| Authors: | Nalinee Aswapokee and Harold C. Neu |
| |
| Affiliation: | *Division of Infectious Diseases, Department of Medicine Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032;1Division of Infectious Diseases, Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032 |
| |
| Abstract: | The in vitro activity of cefazaflur, a parenteral cephalosporin, was determined against 590 clinical isolates. Cefazaflur inhibited the majority of gram-positive cocci at concentrations below 1 mug/ml except for enterococci. The agent was as active as cefamandole or cefoxitin against most Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Although it inhibited a number of strains of Enterobacter, indole-positive Proteus, and Serratia resistant to cephalothin, it was much less active against these organisms than were cefamandole or cefoxitin. |
| |
| Keywords: | |
|
|
