磷酸肌酸对室间隔缺损合并肺动脉高压手术的心肌保护作用

目的观察含血STH2液加入外源性磷酸肌酸（CP）后对室间隔缺损合并肺动脉高压进行室间隔缺损修补术的心肌保护作用。方法20例室间隔缺损合并肺动脉高压患儿随机分为两组,CP治疗组在含血STH2心灌注液中加入CP,对照组用等量含血STH2液,分别在术后16h、第6天,采集患儿静脉血,测磷酸肌酸激酶同工酶（CK-MB）、心肌钙蛋白（cTnT）,同时在术后观察呼吸机辅助呼吸时间、第6天检查患儿左室射血分数,肺动脉压力。结果CP治疗组术后CK-MB、cTnT、呼吸机辅助呼吸时间、左室射血分数、肺动脉压力较对照组相比均有明显改善。结论CP加入心停搏液中能显著提高心肌保护作用,同时可间接降低肺动脉压力。

Study on the Myocardium Protection Effect of Exogenous Creatine Phosphate in Ventricular Septal Defect with Pulmonary Hypertension

Objective To observe the clinical effects of exogenous creatine phosphate adding STH2 cardioplegia in operation of ventricular septal defect with pulmonary hypertension.Methods We observed the clinical effects of 10 children who underwent ventricular septal defect with pulmonary hypertension gaven blood cardioplegia with exogenous creatine phosphate（study group）,in comparison with l 0 children only gaven STH2（control group）.Blood samples were taken to determine the serum concentrations of CK-MB and cTnT before and after anaesthesia,then at 16h and 6 days.We also observed the EF,pulmonary pressure and mechanical ventilation time of study group and control group 6 days later after operation.Results The level of study group of CK-MB and cTnT at 16h and 6 days after operation were significantly lower in the study group than in the control one.We can got same conclusion in EF,pulmonary pressure and mechanical ventilation time.Conclusion STH2 cardioplegia with exogenous creatine phosphate shows effective myocardial protection in ventricular septal defect with pulmonary hypertension