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丙型肝炎感染的模式及其临床价值
引用本文:曹军皓,黄前川,丁进亚,刘莹.丙型肝炎感染的模式及其临床价值[J].解放军医学高等专科学校学报,2009(6):1029-1031.
作者姓名:曹军皓  黄前川  丁进亚  刘莹
作者单位:解放军广州军区武汉总医院检验科,湖北武汉430070
摘    要:目的检测丙型肝炎游离核心抗原、抗体及HCV-RNA病毒载量,探讨丙型肝炎的感染模式及临床意义。方法对179份已经确诊的HCV感染血样,采用酶联免疫法检测HCV抗体和HCV核心抗原,荧光定量PCR检测HCV-RNA,观察丙型肝炎的感染模式。结果丙型肝炎的感染至少存在7种模式:Ⅰ型HCVcAg(-),HCVAb(+),HCV-RNA(-);Ⅱ型HCVcAg(+),HCVAb(-),HCV-RNA(+);Ⅲ型HCVcAg(-),HCVAb(-),HCV-RNA(+);Ⅳ型HCVcAg(+),HCVAb(-)HCV-RNA(-);Ⅴ型HCVcAg(-),HCVAb(+),HCV-RNA(+);Ⅵ型HCVcAg(+),HCVAb(+),HCV-RNA(+);Ⅶ型HCVcAg(+),HCVAb(+),HCV-RNA(-)。结论联合检测HCV抗体、HCVcAg、及HCV-RNA,分析丙型肝炎的感染模式,对丙型肝炎病情的诊断和治疗具有重要意义。

关 键 词:丙型肝炎  感染模式

Modes of Hepatitis C Infection and Their Clinical Significance
Cao Jun-hao,Huang Qian-chuan,Ding Jin-ya,Liu Ying.Modes of Hepatitis C Infection and Their Clinical Significance[J].Clinical Journal of Medical Officer,2009(6):1029-1031.
Authors:Cao Jun-hao  Huang Qian-chuan  Ding Jin-ya  Liu Ying
Institution:( Department of Laboratory, Wuhan General Hospital of Guangzhou Command,PLA, Wuhan 430070, China)
Abstract:Objective To detect the core antigen(cAg),antibody(Ab) and HCV-RNA of hepatitis C and to assess their clinical significance in hepatitis C infection models.Methods Using enzyme-linked immunosorbent assay(ELISA) and fluorescence quantitative PCR,we detected HCVAb,HCVcAg and HCV-RNA in the 179 blood samples of patients with chronic hepatitis C,and summarized the patterns of hepatitis C infection.Results Hepatitis C infected human beings with at least seven modes,i.e.(1) HCVcAg(-),HCVAb(+),HCV-RNA(-);(2) HCVcAg(+),HCVAb(-),HCV-RNA(+);(3) HCVcAg(-),HCVAb(-),HCV-RNA(+);(4) HCVcAg(+),HCVAb(-),HCV-RNA(-);(5) HCVcAg(-),HCVAb(+),HCV-RNA(+);(6) HCVcAg(+),HCVAb(+),HCV-RNA(+);(7) HCVcAg(+),HCVAb(+),HCV-RNA(-).Conclusion Analysis of hepatitis C infection modes through combined serum HCVAb,HCVcAg and HCV-RNA test has great significance in the diagnosis and treatment of HCV.
Keywords:hepatitis C  infection mode
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