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| 复合人工骨与自体骨移植近期融合效果比较研究 | |
| 引用本文： | 张余,尹庆水,李兆麟,徐国洲,黄华扬,张宏斌. 复合人工骨与自体骨移植近期融合效果比较研究[J]. 南方医科大学学报, 2003, 23(9): 937-939,942 |
| 作者姓名： | 张余 尹庆水 李兆麟 徐国洲 黄华扬 张宏斌 |
| 作者单位： | 1. 中山大学地球科学系,广东,广州,510275 2. 广州军区广州总医院,骨科,广东,广州,510010 3. 广州军区广州总医院,医学实验科,广东,广州,510010 |
| 基金项目： | 广东省重点攻关项目科研基金(99M01705G)，广东省自然科学基金团队项目(20023001)~~ |
| 摘 要： | 目的评价复合人工骨材料珊瑚羟基磷灰石-重组人骨形态形成蛋白-几丁糖(coralline hydroxyapatite composite, CHC)做为自体骨移植替代物在手术后10周的融合效果。方法按序贯实验设计方法设计试验,分别以CHC和自体骨应用于骨不连、脊柱融合病例的治疗,于术后10周行X光检查,并按照Lane-Sandhu评分法中骨形成的评定标准来确定愈合情况,以愈合情况为观察指标,选定α=0.05、β=0.05、γ=FS/SF=2进行统计分析。结果去除观察结果相同的2对至第13对时,曲线与上界相交,停止试验。结论从CHC做为骨移植替代物手术后10周的骨融合情况来讲,CHC比自体骨融合效果好。 |
| 关 键 词： | 复合珊瑚羟基磷灰石 生物相容性材料 骨移植 临床序贯试验 生物人工骨 |
| 文章编号： | 1000-2588(2003)09-0937-03 |
| 修稿时间： | 2003-05-21 |
Coparative clinical observation of the short-term bone fusion effect of composite biosynthetic bone and ilium auto-grafting |
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| ZHANG Yu ,YIN Qing-shui ,LI Zhao-lin ,XU Guo-zhou ,HUANG Hua-yang ,ZHANG Hong-bin Academy of Earth and Environment Science,Sun Yat-sen University,Guangzhou ,China, Departments of Orthopedic and Medical Laboratory ,Guangzhou General Hospital of Guangzhou Command,Guangzhou ,China. Coparative clinical observation of the short-term bone fusion effect of composite biosynthetic bone and ilium auto-grafting[J]. Journal of Southern Medical University, 2003, 23(9): 937-939,942 | |
| Authors: | ZHANG Yu YIN Qing-shui LI Zhao-lin XU Guo-zhou HUANG Hua-yang ZHANG Hong-bin Academy of Earth Environment Science Sun Yat-sen University Guangzhou China Departments of Orthopedic Medical Laboratory Guangzhou General Hospital of Guangzhou Command Guangzhou China |
| Affiliation: | ZHANG Yu 1,YIN Qing-shui 2,LI Zhao-lin 1,XU Guo-zhou 2,HUANG Hua-yang 2,ZHANG Hong-bin 31 Academy of Earth and Environment Science,Sun Yat-sen University,Guangzhou 510275,China, Departments of Orthopedic 2 and Medical Laboratory 3,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010,China |
| Abstract: | Objective To evaluate the short-term bone fusion after implantation of composite biosynthetic bone made of coralline hydroxyapatite composite (CHC) as a substitute for autologous bone grafting. Methods A clinical sequential trial was designed and the biosynthetic bone and the patient's ilium were respectively used in the treatment of femoral nonunions and interbody fusion. X-ray examinations were performed 10 weeks after the operations and the bone fusion was graded ac-cording to Lane-Sandhu's method. Results The biosynthetic bone was capable of bone fusion as observed in this experiment. Sequential analysis found that the upper bound was reached when the X-ray examination scores of 15th pairs were transcribed in the chart with 2 pairs of cases dismissed for having the same grade. Conclusion The bone fusion effect of CHC is better than auto-grafting judging from the present observation at 10 weeks after operation. |
| Keywords: | coralline hydroxyapatite composite biocompatible materials bone transplantation clinical sequential trial biosyn-thetic bone |
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