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Recent Trends in the Treatment and Prognosis of Adult Leukemia with Characteristics of Patients in Japan: Transition during the Fifteen Years from 1971 to 1985 |
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| Authors: | Suzuki Hisamitsu; Ota Kazuo; Ohno Ryuzo; Masaoka Toru; Shibata Hirotoshi; Kimura Ikuro; Amaki Ichita; Miura Yasusada; Uzuka Yoshiro; Kawato Masafumi; Shirakawa Shigeru; Hirota Yutaka; Maekawa Tadashi; lmai Kuniyuki; Takaku Fumimaro; Shimoyama Masanori; Kitahara Takeshi; Oguro Masao; Kozuru Mitsuo; Kawagoe Hiroya; Nakamura Toru; Yamada Kazumasa |
| Institution: | 1Department of Internal Medicine, Aichi Cancer Center Hospital 1-1, Kanokoden, Chikusa-ku, Nagoya 464 2First Department of Internal Medicine, Nagoya University, School of Medicine Osaka 3Department of Internal Medicine, Center for Adult Diseases Osaka 4Second Department of Internal Medicine, Okayama University, Medical School 5Department of Internal Medicine, Nihon University, School of Medicine 6Division of Hematology, Department of Medicine, Jichi Medical School, School of Medicine 7Third Department of Internal Medicine, Tohoku University, School of Medicine 8department of Internal Medicine, Second Tokyo National Hospital 9Second Department of Internal Medicine, School of Medicine, Mie University 10Department of Internal Medicine, National Nagoya Hospital 11Third Department of Internal Medicine, School of Medicine, Gunma University 12Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital 13Third Department of Internal Medicine, University of Tokyo, Faculty of Medicine 14Department of Internal Medicine, National Cancer Center Hospital 15Division of Hematology and Chemotherapy, Chiba Cancer Center Hospital 16Department of Hematology and Internal Medicine, National Kyushu Cancer Center Hospital 17Department of Internal Medicine, National Osaka Hospital 18Department of Internal Medicine, Fukui Medical School, Faculty of Medicine 19Department of Internal Medicine, Branch Hospital of Nagoya University, School of Medicine |
| Abstract: | Patients with acute (2,569) and chronic (957) leukemia diagnosedat 19 institutes took part in the study on the "MultidisciplinaryTreatment of Leukemia" between 1971 and 1985 and were investigatedretrospectively. By dividing the 15 years into three five-yearperiods, we were able to compare patient ratios in the differentperiods. The proportions of acute to chronic leukemia casesshowed no obvious change; however, the proportions of casesdiagnosed as acute lymphocytic leukemia in acute leukemia showeda significant increase. The main chemotherapeutic drugs usedduring the three time periods were cytarabine or its analogues,the anthracyclines, 6-mercaputopurine and prednisolone, againstacute myelogenous leukemia, and the vinca alkaloids, prednisoloneand the anthracyclines against acute lymphocytic leukemia. Therate of complete remission from acute myelogenous leukemia mademarked progress, from 45.1% during 1971–1975 to 62.3%during 1981–1985, but that of acute lymphocytic leukemiashowed no significant progress, being 65% during 1971–1975and 69.7% during 1981–1985. The durations of remission,however, and the survival times for patients with acute lymphocyticleukemia, as well as for those with acute myelogenous leukemia,became significantly longer over the three periods. Median survivaltimes from chronic myelocytic leukemia were 37–40 mo inall three periods, showing no progress. There was a better prognosisin cases of chronic myelocytic leukemia with, than without,Philadelphia chromosome. Except for a low incidence of chroniclymphocytic leukemia in Japan, adult leukemia patients' characteristicsand prognoses seem to be almost the same in Japan as in theU.S.A. and Europe. |
| Keywords: | Adult leukemia Acute leukemia Chronic leukemia Incidence Chemotherapy |
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