Hepatocyte growth factor secreted by periodontal ligament and gingival fibroblasts is a major chemoattractant for gingival epithelial cells |
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Authors: | Ohshima M Noguchi Y Ito M Maeno M Otsuka K |
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Affiliation: | Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan. |
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Abstract: | To ascertain whether periodontal fibroblasts could be involved in the pathogenesis of periodontal pocket formation, the chemotactic activity of periodontal ligament fibroblast-conditioned medium (PLF-CM) and gingival fibroblast-conditioned medium (GF-CM) for gingival epithelial cells was examined using a modified Boyden chamber assay. Both PLF-CM and GF-CM possessed significant chemotactic activity, which was decreased markedly by treatment with anti-human hepatocyte growth factor (HGF) neutralizing antibody. Furthermore, the chemotactic activity of PLF-CM and GF-CM was well correlated with HGF content. These results show that PLF and GF secrete an HGF-like factor, and suggest that such a factor derived from periodontal fibroblasts might play a role in epithelial apical migration in periodontitis. |
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Keywords: | periodontal ligament fibroblast (PLF) gingival fibroblast (GF) chemotactic activity gingival epithelial cell hepatocyte growth factor (HGF) |
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