| 兔脊髓缺血再灌注损伤时凝血功能的变化及谷氨酰胺预处理的影响 |
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| 引用本文： | 巩守平,王文涛,钟大林,吕健,吴锋,车金,僧志远,贺西京. 兔脊髓缺血再灌注损伤时凝血功能的变化及谷氨酰胺预处理的影响[J]. 医学争鸣, 2009, 30(3): 251-253 |
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| 作者姓名： | 巩守平 王文涛 钟大林 吕健 吴锋 车金 僧志远 贺西京 |
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| 作者单位： | 巩守平,王文涛,钟大林,吕健,僧志远,GONG Shou-Ping,WANG Wen-Tao,ZHONG Da-Lin,Lü Jian,SENG Zhi-Yuan(西安交通大学医学院,第二附属医院神经外科,陕西,西安,710004);吴锋,车金,WU Feng,CHE Jin(西安交通大学医学院,血液病实验室,陕西,西安,710004);贺西京,HE Xi-Jing(西安交通大学医学院,第二附属医院骨科,陕西,西安,710004) |
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| 摘 要： | 目的：探讨兔脊髓缺血再灌注损伤（SCIRI）时凝血功能的变化、意义及谷氨酰胺预处理对其影响．方法：采用Zivin法建立SCIRI模型，动态观察SCIRI及谷氨酰胺预处理时血液胛（凝血酶原时间），AVIT（部分凝血活酶时间），TT（凝血酶时间）和FIB（纤维蛋白原）的变化．结果：假手术组PT，APTT，FIB逐渐升高（P〉0．05），TT逐渐降低至缺血45min时显著降低然后逐渐升高（P〈0．01）；缺血再灌注组（I／R）凝血四项各项指标逐渐升高，2h达到最高峰后逐渐下降，12h降到缺血前水平，在这一过程中，除门外，45min，2h，6h时间点与缺血前比较均有显著差异（P〈0．01）；谷氨酰胺预处理组凝血4项各项指标与I／R组比较仅有下降趋势（P〉0．05）．结论：SCIRI引起凝血状态显著改变，可能为凝血因子水平、活性及功能改变导致，谷氨酰胺预处理没有改善SCI-RI引起凝血状态改变．
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| 关 键 词： | 谷氨酰胺 脊髓 脊髓缺血再灌注 凝血 |
Coagulation functions in rabbits with spinal cord ischemia-reperfusion injury and effect of glutamine precondition |
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| GONG Shou-Ping,WANG Wen-Tao,ZHONG Da-Lin,WU Feng,CHE Jin,SENG Zhi-Yuan,HE Xi-Jing. Coagulation functions in rabbits with spinal cord ischemia-reperfusion injury and effect of glutamine precondition[J]. Negative, 2009, 30(3): 251-253 |
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| Authors: | GONG Shou-Ping WANG Wen-Tao ZHONG Da-Lin WU Feng CHE Jin SENG Zhi-Yuan HE Xi-Jing |
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| Affiliation: | GONG Shou-Ping1,WANG Wen-Tao1,ZHONG Da-Lin1,Lü Jian1,WU Feng2,CHE Jin2,SENG Zhi-Yuan1,HE Xi-Jing31Department of Neurosurgery,2Department of Genetics and Molecular Biology,3Department of Orthopedic Surgery,Second Affiliated Hospital,Medical College of Xi'an Jiaotong University,Xi'an 710004,China |
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| Abstract: | AIM: To explore the changes of coagulation functions in rabbits with spinal cord ischemia-reperfusion injury(SCIRI) and the effect of glutamine precondition.METHODS: SCIRI model were established with Zivin method in rabbits.PT,APTT,TT and FIB were measured at different time point before and after injury.RESULTS: PT,APTT,TT and FIB of rabbits with SCIRI increased obviously,reached the peak value after reperfusion of 2 hours,then started to decrease and reached the level below pre-ischemia value at the 12th h... |
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| Keywords: | glutamine spinal cord ischemia-reperfusion injury coagulation function |
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