细胞因子与溃疡性结肠炎治疗的研究进展

溃疡性结肠炎(UC)是一种与遗传、免疫、环境等多种因素相关的慢性肠道炎症性疾病,其具体病因、发病机制还不完全清楚。但细胞因子在发病、发展及其预后中的作用已得到公认,前炎症细胞因子和抗炎性因子之间的平衡失调起着关键性作用[1]。众所周知,UC的治疗一直比较棘手,目前仍以氨基水杨酸和激素为主,西医及中医疗法虽然取得较大成效,但并未获得突破性进展。鉴于细胞因子在其发病中的作用,已开展应用细胞因子及其拮抗剂类药物的治疗途径,此文就细胞因子与UC的治疗作一综述。

Research progress on cytokines in treatment of ulcerative colitis

Ulcerative colitis is a chronic inflammatory bowel disease of the gastrointestinal tract, and it results from a complex interplay of genetic, environmental and immunologic factors. The precise mechanisms underlying etiology and pathogenesis of UC have remained obscure. It is well known that cytokines play a central role in modulating inflammation, especially in the imbalance of proinflammatory cytokines and anti-inflammatory cytokines. Therapy of UC has improved and expanded as the understanding of disease mechanisms such as traditional Chinese medicine, but it mainly included aminosalicylates and corticosteroids. With the development of cytokines, the new research including monoclonal antibodies will open new and exciting perspectives on the development of therapies for UC. The research progress on cytokines in treatment of ulcerative colitis will be reviewed in the article.