| 替米沙坦降低血糖正常的胰岛素抵抗大鼠肾脏血管内皮生长因子及其受体的表达 |
| |
| 引用本文： | 焦亚彬,姚丽,于艳秋,魏丹丹,刘美娜,马玲,王力宁.替米沙坦降低血糖正常的胰岛素抵抗大鼠肾脏血管内皮生长因子及其受体的表达[J].中华内分泌代谢杂志,2010,26(9). |
| |
| 作者姓名： | 焦亚彬 姚丽 于艳秋 魏丹丹 刘美娜 马玲 王力宁 |
| |
| 作者单位： | 1. 中国医科大学附属第一医院肾内科,沈阳,110001
2. 中国医科大学病理生理教研室 |
| |
| 摘 要： | RT-PCR和免疫组化结果显示,血糖正常阶段胰岛素抵抗大鼠肾脏皮质血管内皮生长因子(VEGF)及其受体(flk-1)表达显著升高,替米沙坦可明显降低其表达,提示替米沙坦可通过下降VEGF、flk-1的表达减轻肾脏损害.
|
| 关 键 词： | 胰岛素抵抗 血管内皮生长因子 替米沙坦 |
Telmisartan decreases vascular endothelial growth factor and its receptor expressions in the kidney of insulin resistant rats with normal blood glucose |
| |
| JIAO Ya-bin,YAO Li,YU Yan-qiu,WEI Dan-dan,LIU Mei-na,MA Ling,WANG Li-ning.Telmisartan decreases vascular endothelial growth factor and its receptor expressions in the kidney of insulin resistant rats with normal blood glucose[J].Chinese Journal of Endocrinology and Metabolism,2010,26(9). |
| |
| Authors: | JIAO Ya-bin YAO Li YU Yan-qiu WEI Dan-dan LIU Mei-na MA Ling WANG Li-ning |
| |
| Abstract: | The results of RT-PCR and immunohistochemistry showed that the expressions of vascular endothelial growth factor (VEGF) and its receptor ( flk-1 ) in the renal cortex of insulin-resistant rats during the phase of normal blood glucose were significantly increased, which were decreased by telmisartan. The result suggests that telmisartan may ease kidney damage via decreasing VEGF and flk-1 expressions. |
| |
| Keywords: | Insulin resistance Vascular endothelial growth factor Telmisartan |
| 本文献已被 万方数据 等数据库收录！ |
|
