Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. |
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| Authors: | R Rappuoli M Pizza G Douce G Dougan |
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| Affiliation: | IRIS, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy. rino_rappuoli@biocine.it |
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| Abstract: | Escherichia coli heat-labile enterotoxin and cholera toxin are potent mucosal immunogens and adjuvants in animal models. Non-toxic mutants retaining adjuvant activity are useful tools to dissect the mechanism of mucosal adjuvanticity and promising candidates for development of human vaccines and immunotherapy. Clinical trials are expected to proceed in the near future. |
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