高血压肥胖患者血清和脂肪组织脂蛋白脂酶测定及临床意义

目的探讨高血压肥胖患者血清、脂肪组织中脂蛋白脂酶含量与血脂紊乱、胰岛素抵抗、肥胖、高血压等代谢紊乱的关系.方法选取住院的腹部手术患者48例为研究对象,高血压肥胖患者及正常对照组各24例,测定血压、体重指数、腰臀比、血脂、血糖、胰岛素以及血清和大网膜脂肪组织脂蛋白脂酶的含量.结果高血压肥胖组患者的甘油三酯(TG)、胰岛素(INS)、空腹血糖(FBS)均显著高于对照组(P＜0.01),血清脂蛋白脂酶(LPL)含量、高密度脂蛋白(HDL)显著低于对照组(P＜0.01),血清总胆固醇(TC)(P＞0.05)、低密度脂蛋白胆固醇(LDL-C)(P＞0.05)无明显差别.高血压肥胖组大网膜脂肪组织LPL的含量与对照组无显著差别(P＞0.05).血清LPL含量与体重指数(BMI)(r=-0.640,P＜0.01)、腰臀比(WHR)(r=-0.589,P＜0.01)、TG(r=-0.784,P＜0.01)负相关;与胰岛素敏感指数(ISI)(r=0.533,P＜0.01)、HDL(r=0.463,P<0.01)正相关,与TC(r=-0.222,P＞0.05)、LDL(r=-0.213,P＞0.05)无相关性;脂肪组织LPL含量与上述指标均无相关性(P＞0.05).结论肝素前LPL的含量与高血压肥胖患者的发病及代谢紊乱显著相关;脂肪组织LPL含量与血清LPL含量及肥胖高血压患者的代谢紊乱无明显关联.

Measurements of lipoprotein lipase of serum and its adipose tissue and its clinical significance

Objective To investigate the relationship between serum lipoprotein lipase(LPL) content, great omentum adipose tissue lipoprotein lipase content and dyslipidemia,insulin resistance, obesity and hypertension in obesity-related hypertension patients. Methods The subjects who were inpatients and performed abdominal operation were selected in present study, 24 obesity-related hypertension and 24 age,sex-matched normal body mass individuals were studied. Blood pressure,body mass index(BMI),waist-hip ration(WHR),serum lipid,serum glucose,insulin(INS),LPL in serum and great omentum adipose tissue was measured in every subject. Results The values of triglyceride(TG),INS,fast blood sugar in the group of obesity-related hypertension were significantly higher than those in the normal body mass group(P< 0.01),the values of serum LPL content and high density lipoprotein-C(HDL-C) were the reverse (P< 0.01).The values of total cholesteral(TC)(P> 0.05) and low density lipoprotein-C(LDL-C) (P> 0.05) had no difference. The values of great omentum adipose tissue LPL content in the group of obesity-related hypertension had no significantly difference with control group(P> 0.05);serum LPL content was significantly negatively correlated with BMI(r= -0.640,P< 0.01), WHR(r= -0.589,P< 0.01) and TG(r= -0.784,P< 0.01),but positively correlated with insulin sensitive index (r= 0.533,P< 0.01),HDL-C(r= 0.463,P< 0.01), has no correlated with TC(r= -0.222,P> 0.05),LDL-C(r= -0.213, P> 0.05); great omentum adipose tissue LPL content has no correlation with the above related index(P> 0.05).Conclusion Serum preheparin LPL content is significantly correlated with onset of hypertension and its metabolic disorder; great omentum adipose tissue LPL content has no significant correlation with serum LPL content and metabolic disorder of obesity-related hypertension patients.