五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响

本研究观察了五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响。结果表明,该方可升高老龄大鼠下丘脑去甲肾上腺素(NE)含量,降低5-羟色胺(5-HT)含量和5-HT/多巴胺(DA)比值;升高老龄大鼠血浆睾酮(T)含量,降低雌二醇(E_2)/T比值;提高雄性大鼠精子活动度、精子计数和生育能力。

Effect of Wuzi Yanzong Liquid on Hypothalamus,Monoamines, Sexual Hormones and Reproductivity in Male Rats

About 100 male SD rats aged 2, 5, 10, 18 and 24 months (each age group for about 20 rats) wereused in the antisenility experiment. The animals of each age group were further subdivided into twogroups randomly: one group administered with Wuzi Yanzong Liquid (WYL) daily for 5 weeks, andthe other group with normal saline. After treatment, plasma testosterone (T) and estradiol (E2),hypothalamus norepinephrine (NE), dopamine (DA) and serotonin (5-HT) levels were determined. Incomparison with younger groups, the 18 and 24 months old rats administered with saline hadmarkedly lowered plasma T, hypothalamus NE and DA levels, and elevated 5-HT, E2 levels and 5-HT/DA, E2/T ratios; while in the 18 and 24 months rats administered with WYL the abovementioned changes were much less remarkable. Since WYL only raised plasma T level in old rats but not in younger ones, this drug seems to have different action from testosterone preparations. Inanother animal experiment, the reproduction promoting effect of WYL was shown by the increaseof sperm count and motility of sperms in old male rats as well as its reproductive ability.