小儿先天性心脏病合并肺动脉高压的药物治疗

先天性心脏病的患儿常合并有肺动脉高压,对于病程的变化和手术及药物治疗方案产生很大的影响。目前随着药物学的发展,临床上逐渐采用了诸如一氧化氮、磷酸二酯酶抑制剂、前列腺素类药物和内皮素拮抗剂等药物,配合先天性心脏病手术,通过单独给药和联合给药的方式,针对术前和术后的肺动脉高压进行治疗,已经取得了良好的效果。文章对这些药物各自的特点和应用进行综述。

Medical treatment for children with pulmonary hypertension associated With congenital heart diseases

Patients with congenital heart disease are usually associated with pulmonary arterial hypertension which affects the natural history,surgical protocol and medical treatment of disease. With the development of new drugs,some such as nitric oxide,inhibitors of phosphodiesterase,prostaglandin and endothelin antagonists are widely used to treat pulmonary arterial hypertension developed before or after surgery,and have improved the outcome of surgery. This article reviews the functions and use of these drugs.