Lipid peroxidation parameters in the internal organs of rats with different degrees of resistance to hypoxia |
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| Authors: | M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko |
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| Affiliation: | (1) Department of Experimental Biological Models, Moscow;(2) Department of Mathematical Methods, Russian State Medical University, Moscow;(3) Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming that oxidation plays a major role in the damaging and lethal effects of acute hypoxia. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N o 1, pp 26–29, January, 1996 Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | lipid peroxidation antioxidant system hypoxia low resistance high resistance |
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