Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy |
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Authors: | Mary L Ostrowski Mark E Johnson Luan D Truong M John Hicks Frank E Smith Harlan J Spjut |
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Institution: | (1) Department of Pathology and Laboratory Medicine, Baylor College of Medicine, The Methodist Hospital and Texas Children’s Hospital, Houston, Texas, USA, US;(2) Department of Orthopedic Surgery, Baylor College of Medicine, The Methodist Hospital and Texas Children’s Hospital, Houston, Texas, USA, US;(3) Department of Oncology, Baylor College of Medicine, The Methodist Hospital and Texas Children’s Hospital, Houston, Texas, USA, US;(4) Department of Pathology and Laboratory Medicine MS#205, The Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA, US |
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Abstract: | We report a rare case of malignant chondroblastoma, which presented in a 47-year-old man as a recurrent tumor, 18 years following
wide excision of a typical pelvic chondroblastoma. Radiologic studies of the recurrent tumor showed a large, lytic, destructive
lesion of the right pelvic bones and femur, with a pathologic fracture of the latter, a large pelvic soft tissue mass, and
multiple pulmonary metastases. Biopsy tissue showed typical features of chondroblastoma, but also increased nuclear atypia,
hyperchromasia, and pleomorphism, compared to the original tumor, and, most significantly, abnormal mitotic figures. Immunohistochemical
studies of the recurrent tumor revealed p53 mutation and extensive proliferative activity, and flow cytometric studies showed
DNA aneuploidy, none of which was present in the original tumor. The patient received chemotherapy and radiation, but died
of disease eight months after presentation. We also review chondroblastoma in general, to assign this unusual lesion to a
tumor subtype.
Received: 29 March 1999 Revision requested: 27 April 1999 Revision received: 23 June 1999 Accepted: 29 June 1999 |
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Keywords: | Chondroblastoma malignant recurrent p53 mutation Aneuploidy Pelvis Femur Xray CT |
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