三维打印成形技术制备药物梯度控释给药系统研究

 目的研究利用三维打印成形技术制备具有药物梯度特征的控释给药系统。方法以双氯芬酸钠为模型药物,利用三维打印技术制备其浓度梯度控释给药系统,通过常规分析、结构分析、体外释药试验检验所制备给药系统的基本性能、结构特征和释药特征。结果所制备给药系统的各项指标符合相关片剂标准,轴向能够阻止药物释放,径向药物呈梯度分布,98.14%的药物能按零级释放。结论应用三维打印成形技术可以制备具有特殊的结构组成和表面特性的给药系统,从而获得所需释药特征。

Studies on Preparation of Controlled-Release Delivery Systems with Drug Gradients Using Three Dimensional Printing Technique

OBJECTIVE To prepare controlled-release delivery systems with drug gradients using three dimensional printing technique.METHODS With diclofenac sodium as model drug,controlled-release delivery systems with drug gradients were prepared using three dimensional printing technique.Basic performance,structure properties,and release characteristics were investigated through the routine tablet analysis,structure analysis,dissolution tests in vitro.RESULTS All parameters of drug delivery systems met the relevant standards,drug release from the axial direction was retarded completely,and drug distribution was gradient in the radial direction,98.14% drug was released at a zero-order rate.CONCLUSION Drug delivery systems with special properties of components,structure and surface texture to provide the desired release characteristics could be fabricated by three dimensional printing technique.