Homocisteína plasmática en la preeclampsia y eclampsia durante el pre y posparto

Objective

To compare plasma homocysteine concentrations in preeclamptic, eclamptic and normotensive pregnant patients before and after delivery.

Methods

We included 30 patients with mild preeclampsia (group A), 30 patients with severe pre-eclampsia (group B), and 30 patients with eclampsia (group C). A control group of 35 normotensive women (group D) was selected with a similar age and body mass index as the study groups. In all groups, blood samples were collected in all patients before delivery, and post-partum follow-up samples were collected at 7 days and 6 weeks.

Results

Statically significant differences were found between controls and the three study groups in birthweight (P<.05). Before delivery, the highest concentrations were seen in eclamptic patients followed by those with severe preeclampsia. Concentrations were significantly higher in the three study groups than in controls (P<.05). At 7 days and 6 weeks, mean homocysteine concentrations were significantly higher in groups A, B and C than in group D (P<.05).

Conclusions

Homocysteine concentrations were significantly higher in pre-eclamptic and eclamptic patients than in normotensive pregnant women and remained higher at 6 weeks after delivery.