Cognitive dysfunctions in elderly cancer patients: A new challenge for oncologists |
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| Authors: | Marie Lange,Olivier Rigal,Bé né dicte Clarisse,Bé né dicte Giffard,Emmanuel Sevin,Marie Barillet,Francis Eustache,Florence Joly |
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| Affiliation: | 1. INSERM, U1077, Caen, France;2. Normandie Université, UMR-S1077, Caen, France;3. Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France;4. CHU de Caen, U1077, Caen, France;5. INSERM, U1086, Caen, France;6. Unité de Recherche Clinique, Centre François Baclesse, Caen, France;g Centre Henri-Becquerel, Département d’oncologie médicale, Rouen, France;h Comité Urologie-Gynécologie, Centre François Baclesse, Caen, France;i CHU de Caen, Service de médecine, Caen, France |
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| Abstract: | While chemotherapy is more commonly proposed to the elderly population with cancer, little is known about the impact of therapy on cognitive functions and the way of managing such dysfunctions in clinical practice among this population. Aging by itself is associated with cognitive modifications, comorbidities and functional decline, which may have a significant impact on the autonomy. In elderly patients with cancer, several factors like the biologic processes underlying the disease and therapies will contribute to favor the cognitive decline. The chemobrain phenomenon, referring to the chemotherapy-induced impairment of memory, executive function or information processing speed has been extensively described in patients with breast cancer, and the few studies available in older patients suggest that the impact could be more pronounced in patients with pre-existing troubles. |
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| Keywords: | Cancer Cognition Elderly Chemotherapy Oncogeriatric assessment |
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