Evolución clínica y paraclínica de 9 embarazos en 4 pacientes con enfermedad de Gaucher tipo 1 en el servicio de hematología de un hospital docente asistencial

Objectives

To describe the clinical presentation and course in a group of pregnant women with Gaucher disease type 1.

Subjects and methods

Pregnant women admitted to our hematology service with a medical diagnosis of Gaucher disease type 1.

Results

All patients were classified as high risk. We describe 9 pregnancies in 4 patients: 7 were on enzyme replacement therapy before the pregnancy and continued to receive this therapy throughout the pregnancy; 1 patient discontinued therapy 8 months previously and had a hematological exacerbation.

Conclusions

Pregnancy should not be contraindicated in patients with stable disease. Enzyme replacement therapy should not be interrupted or suspended because it decreases complications.