Antimicrobial efficacy of a novel silver hydrogel dressing compared to two common silver burn wound dressings: Acticoat™ and PolyMem Silver |
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Authors: | Benjawan Boonkaew Margit Kempf Roy Kimble Pitt Supaphol Leila Cuttle |
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Affiliation: | 1. Centre for Children''s Burns and Trauma Research, Queensland Children''s Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia;2. The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, Thailand |
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Abstract: | A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel dressing to two commercially available silver dressings; Acticoat™ and PolyMem Silver®. Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9–18.4 mm. It reduced the microbial inocula below the limit of detection (102 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94–99% after 24 h exposure. These results support the possibility of using this novel silver hydrogel as a burn wound dressing in the future. |
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Keywords: | Silver Dressing Antimicrobial Live/Dead Disc diffusion Broth culture |
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