| 二维应变超声心动图评价大鼠心肌收缩应变与梗死面积的相关性 |
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| 引用本文： | 林美燕,阮琴韵,廖书生,鄢磊.二维应变超声心动图评价大鼠心肌收缩应变与梗死面积的相关性[J].福建医科大学学报,2009,43(6):467-470. |
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| 作者姓名： | 林美燕 阮琴韵 廖书生 鄢磊 |
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| 作者单位： | 福建医科大学,附属第一医院超声科,福州350005 |
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| 基金项目： | 福建医科大学教授学术发展基金 |
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| 摘 要： | 目的应用二维应变超声心动图（2DSE）技术检测心梗大鼠左室壁的径向、周向应变及应变率,以组织学上心肌梗死面积为标准,探讨2DSE技术对评价梗死心肌的价值。方法开胸制备17只大鼠急性心梗模型,于术前24 h、术后4周分别行超声心动图检查,应用2DSE技术分析左室短轴乳头肌水平各节段收缩期峰值径向、周向应变及应变率,心肌梗死后4周心脏标本行组织学染色后计算梗死心肌面积。结果（1）与术前相比,术后4周各节段径向、周向应变及应变率均显著降低,以梗死区降低最为显著（P〈0.05）;（2）2DSE的径向、周向应变及应变率指标与梗死面积均呈显著负相关,以径向应变〈10%判断节段心肌梗死面积〉30%的灵敏度和特异度分别为0.84,0.98。结论2DSE技术可用于评价心肌梗死大鼠局部心肌功能,对判断节段心肌梗死面积〉30%有较高的准确性。
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| 关 键 词： | 心肌梗死 心肌收缩 超声心动描记术 疾病模型 动物 |
Correlations between Myocardial Systolic Strain and Infarct Area in a Rat by 2-Dimensional Strain Echocardiography |
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| LIN Meiyan,RUAN Qinyun,LIAO Shusheng,YAN Lei.Correlations between Myocardial Systolic Strain and Infarct Area in a Rat by 2-Dimensional Strain Echocardiography[J].Journal of Fujian Medical University,2009,43(6):467-470. |
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| Authors: | LIN Meiyan RUAN Qinyun LIAO Shusheng YAN Lei |
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| Institution: | LIN Meiyan,RUAN Qinyun,LIAO Shusheng,YAN LeiDepartment of Ultrasound,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,China |
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| Abstract: | Objective This experimental study was aimed to investigate the correlations between regional myocardial systolic strain and infarct area in a rat myocardial infarction model by 2-dimensional strain echocardiography(2DSE).Methods An animal model of myocardial infarction was established by opening chest and ligating the proximal left anterior descending coronary artery(LAD) in 17 SD rats.Regional myocardial function was detected by 2DSE at baseline and 4-weeks post-infarction,including end-systolic radial str... |
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| Keywords: | myocardial infarction myocardial contraction echocardiography disease models animal |
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