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| 肾衰3号颗粒剂对阿霉素肾病大鼠转化生长因子-β1表达的影响 | |
| 引用本文： | 孙元莹,郭茂松,张万祥,刘红栓,张琪. 肾衰3号颗粒剂对阿霉素肾病大鼠转化生长因子-β1表达的影响[J]. 中国中西医结合急救杂志, 2004, 11(6): 345-348 |
| 作者姓名： | 孙元莹 郭茂松 张万祥 刘红栓 张琪 |
| 作者单位： | 1. 天津市第一中心医院,天津,300192 2. 黑龙江省中医研究院,黑龙江,哈尔滨,150036 3. 天津中医学院,天津,300193 |
| 摘 要： | 目的:观察慢性肾功能衰竭(CRF)转化生长因子-β1(TGF-β1)的表达,探讨中药肾衰3号颗粒剂缓解CRF恶化的作用机制.方法:60只Wistar大7.5 mg/kg造成阿霉素肾病模型；观察24 h尿蛋白量、血肌酐(SCr)、尿素氮(BUN)、肌酐清除率(CCr)及肾小管间质病理变化;免疫组化法观察TGF-β1、血小板源性生长因子-β(PDGF-β)在肾脏的表达及药物影响.结果:中药高剂量组尿蛋白含量、SCr、BUN改善程度均较其他治疗组明显,与模型组相比差异显著(P均<0.01);肾小管间质病变减轻最为明显;TGF-β1主要表达于肾小球内皮细胞和肾小管上皮细胞,PDGF-β主要表达于肾小球系膜区及肾小管近曲和远曲上皮细胞,且阳性表达率均为各组最低(TGF-β1为25.0%,PDGF-β为33.3%).结论:肾衰3号颗粒剂对CRF的保护作用机制可能是通过下调TGF-β1表达而减少肾小球细胞外基质沉积,下调PDGF-β表达而减少肾小球系膜细胞过度增殖. |
| 关 键 词： | 慢性肾功能衰竭 转化生长因子-β1 血小板源性生长因子-β |
| 文章编号： | 1008-9691(2004)06-0345-04 |
| 修稿时间： | 2004-04-14 |
Effects of Shenshuai pallet Ⅲ (肾衰3号颗粒剂) on expression of transforming growth factor-β1 in adriamycin-nephritis rats |
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| SUN Yuanying ,GUO Maosong ,ZHANG Wanxiang ,LIU Hongshuan ,ZHANG Qi . . Tianjin The First Central Hospital,Tianjin ,China, . Heilongjiang Institute of Traditional Chinese Medicine,Haerbin ,Heilongjiang,China, . Tianjin Traditional Chinese Medical College,Tianjin ,China. Effects of Shenshuai pallet Ⅲ (肾衰3号颗粒剂) on expression of transforming growth factor-β1 in adriamycin-nephritis rats[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 2004, 11(6): 345-348 | |
| Authors: | SUN Yuanying GUO Maosong ZHANG Wanxiang LIU Hongshuan ZHANG Qi . . Tianjin The First Central Hospital Tianjin China . Heilongjiang Institute of Traditional Chinese Medicine Haerbin Heilongjiang China . Tianjin Traditional Chinese Medical College Tianjin China |
| Affiliation: | SUN Yuanying 1,GUO Maosong 2,ZHANG Wanxiang 1,LIU Hongshuan 3,ZHANG Qi 2. 1. Tianjin The First Central Hospital,Tianjin 300192,China, 2. Heilongjiang Institute of Traditional Chinese Medicine,Haerbin 150036,Heilongjiang,China, 3. Tianjin Traditional Chinese Medical College,Tianjin 300193,China |
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| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |