角膜缘干细胞联合羊膜移植治疗翼状胬肉疗效观察

目的:观察自体角膜缘干细胞移植与羊膜移植术治疗翼状胬肉的临床疗效。方法:将126例142眼翼状胬肉患者随机分成A,B组,A组64例72眼行翼状胬肉切除联合角膜缘干细胞移植术;B组62例70眼行翼状胬肉切除联合羊膜移植术,术后1wk;1mo及3mo,观察比较移植片生长、角膜创面修复、角膜新生血管及胬肉复发率。术后随访24mo。结果:A、B两组角结膜上皮愈合时间分别为(2.6±0.4)d和(3.2±0.7)d,两组比较差异有显著性差异(P<0.05);A组2例2眼翼状胬肉复发,治愈率为97.1%,复发率2.9%;B组9例12眼翼状胬肉复发,治愈率为81.8%,复发率18.2%;两组比较差异有统计学意义(P=0.003)。结论:自体角膜缘干细胞移植与羊膜移植术均可有效防止翼状胬肉的复发,具有方便、创伤小,修复快,术后患者自觉症状轻,复发率低等优点。

Observation of limbal stem cell and amniotic membrane transplantation for treatment of pterygium

AIM:To observe the limbal stem cell transplantation and amniotic membrane transplantation for treatment of pterygium.·METHODS:A total of 126 cases (142 eyes) with wing-shaped pterygium were randomly divided into A,B group,A group of 64 cases (72 eyes) underwent pterygium excision combined with limbal stem cell transplantation;B group of 62 cases (70 eyes) underwent pterygium excision with amniotic membrane transplantation.1 week,1 month,and 3 months after operation,the growth of grafts,corneal wound healing,corneal new blood tube and pterygium recurrence rate were observed and compared.Postoperative follow-up of 24 months.was conducted.·RESULTS:A and B groups conjunctiva epithelial healing time was (2.6±0.4) day and (3.2±0.7) day,the difference was significant (P<0.05);A group had 2 cases (2 eyes) with pterygium recurrence,the cure rate was 97.1%,the recurrence rate of 2.9%;B group had 9 cases(12 eyes) with pterygium recurrence,the cure rate was 81.8%,the recurrence rate of 18.2%;difference between the two groups was statistically significant (P=0.003).·CONCLUSION:Self limbal stem cell transplantation and amniotic membrane transplantation can be effective in preventing the recurrence of pterygium,with advantages of less trauma,fast repair,mild postoperative symptoms and low recurrence rate.