Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey |
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Authors: | M Onofrj M F Ghilardi M Basciani J Martinez-Tica A Glover |
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Affiliation: | Department of Neurology, State University of Chieti, Italy. |
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Abstract: | Median nerve somatosensory evoked potentials (SEP) were recorded in 7 Cynomolgus monkeys, before and after the administration of N-Methyl 1,4 Phenyl 1,2,3,6 tetrahydropiridine (MPTP), a neurotoxin which induces a parkinsonian syndrome in primates. Following MPTP administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (N15) decreased by 70% or more. This amplitude reduction was not modified by administration of dopamine precursors. These findings shed light on recent findings in human parkinsonian patients. |
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