黄芪治疗原发性肾病综合征的疗效观察

目的 :探讨黄芪治疗原发性肾病综合征的疗效。方法 :将 97例肾病综合征患者随机分三组 ,泼尼松组 (对照组 )、丹参组 (泼尼松 +丹参 )、黄芪组 (泼尼松 +黄芪 ) ,观察三组患者治疗前后尿蛋白、血清白蛋白、血脂变化及症状、体征改善情况。结果 :三组治疗后均见尿蛋白减少、血清白蛋白升高和总胆固醇下降 (P <0 .0 1) ,但黄芪组与丹参组和对照组相比 ,黄芪组在使尿蛋白减少、血清白蛋白升高和总胆固醇下降方面尤为明显 (P <0 .0 1) ;黄芪组在水肿消退、腹胀改善方面明显好于丹参组及对照组 (P <0 .0 5 )。结论 :黄芪能减少原发性肾病综合征患者的尿蛋白排泄 ,提高血清白蛋白 ,降低血脂水平及改善相应的临床症状。

Effect of Astragalus menbranaceus in treatment of primary nephrotic syndrome

Objective:To investigate the curative effect of Astragalus menbranceus in treatment of primary nephrotic syndrome.Methods:Ninety seven patients were divided into three groups at random:the group A was treated with prednisone,the group B treated with prednisone and Salvia miltiorrhiza,and the group C treated with prednisone and Astragalus menbranaceus.The changes in their urine protein,serum albumin,blood fat,and their symptoms and signs before and after the treatment were observed.Results:The decrease of urine protein,increase of serum albumin and lowering in total cholesterol were found in the three groups.After the treatment in the group treated with Astragalus menbranaceus,the decrease of urine protein,the lower of total cholesterol and the increase of serum albumin are more significant than those in the other two groups( P < 0.01 ).Meanwhile,the relief in edema and abdominal fluctuation in the group treated with Astragalus mengranaceus was more significant than that of the other two groups( P <0.05).Conclusions:Astragalus menbranaceus can decrease excretion of urine protein,increase serum albumin,lower blood fat level and relieve the clinic symptoms in patients with primary nephrotic syndrome.