FD和IBS病人中抑郁、焦虑患病率及其影响因素

目的：了解综合医院门诊功能性消化不良（functional dyspepsia，FD）和肠易激综合征（irritable bowel syndrome，IBS）患者中抑郁症、焦虑症的息病率；探讨其可能的危险因素。方法：调查成都市三家综合医院内FD和IBS门诊患者；对医院焦虑抑郁量表（HAD）评分≥9分的患者由精神科医生使用Hamilton量表进一步确诊。使用SPSS12．0和SAS8．0软件分析结果。结果：调查病例208例，男性75例，女性133例。其中FD患者100例，IBS患者108例。焦虑或抑郁的患病率25．48％，其中单纯抑郁患病率19．71％，单纯焦虑患病率22．12％，抑郁合并焦虑的患病率16．35％。可能的危险因素有：伴随有其它器质性疾病、发生生活事件、自觉目前健康状况差，离婚、丧偶或分居及中壮年人群，其OR值分别为2．590，2．782，4．096，3．569和3．877。结论：FD和IBS病人中抑郁症、焦虑症的患病率高，抑郁症和焦虑症共病率高；伴随有其它器质性疾病、发生生活事件、自觉目前健康状况差、离婚、丧偶或分居以及中壮年人群是可能的危险因素。

STUDY ON PREVALENCE AND RISK FACTOR OF DEPRESSION/ANXIETY IN FD AND IBS OUTPATIENTS IN COMPREHENSIVE HOSPITAL

Objective:To investigate the prevalence of anxiety and depression in the outpatients of irritable bowel syndrome(IBS)and functional dyspepsia(FD)in comprehensive hospitals,and to explore the risk factors of depression and anxiety.Methods:The survey was carried out in three comprehensive hospitals in Chengdu.The eligible patients were face to face interviewed by trained inquirers using specific questionnaire.The patients were screened by Hospital Anxiety and Depression Scale(HADS),and the ones who get equal or more than 9 points were assessed with Hamilton anxiety scale(HAMA) and Hamilton depression scale(HAMD) by psychiatric doctors.Results:The data of 208 patients were collected,in which 100 patients was FD,108 patients was IBS,75 patients were male and 133 patients were female.The prevalence of anxiety or depression was 25.48%,19.71% patients were identified as depression,22.12%as anxiety,16.35%as depression complicated with anxiety disorder.A multiple factor regression analysis showed that risk factors were coexisting with other organic diseases,,life events,current poor health condition,poor marriage condition and middle-aged people,OR of these factors were 2.590,2.782,4.096,3.569,3.877 respectively.Conclusion:The prevalence of anxiety and depression in the outpatients of IBS and FD is high,but diagnosis rate is low.Coexisting with other organic diseases,life events,current poor health condition,bad marriage condition and middle-aged people may be the risk factors of depression and anxiety.