西医常规疗法结合中医护肝保健操治疗慢性乙型肝炎后肝纤维化临床研究

目的评价西医常规疗法结合中医护肝保健操治疗慢性乙型肝炎后肝纤维化的临床疗效。方法将238例病例随机分为治疗组(120例)和对照组(118例)。两组均予西医常规治疗方案,治疗组同时予中医护肝保健操干预。两组疗程均为6个月,观察临床综合疗效及肝功能、肝纤维化相关指标的变化情况。结果治疗组、对照组总有效率分别为88.3%、71.2%,治疗组临床综合疗效优于对照组(P0.05)。治疗前后组内比较,两组ALT、AST、TBIL、Alb水平差异均有统计学意义(P0.05);组间治疗后比较,ALT、AST及Alb差异有统计学意义(P0.05)。治疗前后组内比较,两组HA、LN、PCIII及CIV水平差异均有统计学意义(P0.05);组间治疗后比较,各指标差异均有统计学意义(P0.05)。结论常规治疗结合中医护肝保健操能有效改善慢性乙型肝炎后肝纤维化,预防早期肝硬化。

Clinical study on combination of western routine treatment and Chinese liver-protection exercises for the treatment of liver fibrosis following chronic hepatitis B

  Objective: To observe the clinical efficacy of western routine treatment and Chinese liver-protection exercises for the treatment of liver fibrosis following chronic hepatitis B  Methods: Two hundred and thirty-eight cases were randomized into treatment group (120 cases) and control group (118 cases). Both groups were treated with western routine therapeutic regimen, and treatment group was added with Chinese liver-protection exercises, with the course of 6 months. The clinical efficacy, indexes of liver function and hepatic fibrosis were observed  Results: The total effective rate was 88.3% in the treatment group and 71.2% in the control group, the comprehensive clinical efficacy in the treatment group was superior to the control group (P<0.05). In both groups, there were significant differences in the levels of ALT, AST, TBIL and Alb between before and after treatment (P<0.05); after treatment, there were significant differences in the levels of ALT, AST and Alb between the two groups (P<0.05). In both groups, there were significant differences in the levels of HA, LN, PCIII and CIV between before and after treatment (P<0.05); after treatment, there were significant differences in all indexes between the two groups (P<0.05)  Conclusion: Combination of routine treatment and Chinese liver-protection exercises can improve the liver fibrosis following chronic hepatitis B, and prevent earlier cirrhosis.