| 尼群地平对6例高血压病人的药物动力学和药效学 |
| |
| 引用本文： | 许景峰,普文英,黄祥,刘祚永,田红. 尼群地平对6例高血压病人的药物动力学和药效学[J]. 中国新药与临床杂志, 1991, 0(4) |
| |
| 作者姓名： | 许景峰 普文英 黄祥 刘祚永 田红 |
| |
| 作者单位： | 北京军区总医院，北京军区总医院，北京军区总医院，北京军区第262医院，北京军区第262医院 北京 100700，北京 100700，北京 100700，北京 100034，北京 100034 |
| |
| 摘 要： | 以反相高效液相色谱内标定量法对6名原发性高血压志愿受试者口服尼群地平0.5mg/kg进行药物动力学和药效学研究。血药浓度-时间曲线为二室开放模型;药动学参数:Ka=0.71±0.15h~(-1),T_(max)=1.5h,C_(max)=67ng/mL。血药浓度与血压下降明显相关(r=-0.819);最大作用维持时间为2-6h。
|
| 关 键 词： | 尼群地平 高血压 药物动力学 |
Pharmacbkineties and pharmacodynamics of nitrendipine in 6 hypertensive patients |
| |
| XU Jing-Feng,PU Wen-Ying,HUANG Xiang,LIU Zuo-Yong,TIAN Hong. Pharmacbkineties and pharmacodynamics of nitrendipine in 6 hypertensive patients[J]. Chinese Journal of New Drugs and Clinical Remedies, 1991, 0(4) |
| |
| Authors: | XU Jing-Feng PU Wen-Ying HUANG Xiang LIU Zuo-Yong TIAN Hong |
| |
| Affiliation: | XU Jing-Feng,PU Wen-Ying,HUANG Xiang,LIU Zuo-Yong1,TIAN Hong1 |
| |
| Abstract: | Pharrnacokinetics and pharmacodynamics of nitrendipine were studied in 6 volunteers with primary essential hypertension. Following the time course of 0,5 mg/kg per os, the pharmacokinetics parameters coincided with a 2-compartment open model, with Ka = 0.71±0.15h-1, T = 1.18±0.22 h, r= 11.7±2.5 h, Cl= 33±5 L/h, AUC = 74±16 ng-h/mL, Tmax =1.5 h, Cmax = 67 ng/mL. Falling of blood pressure was closely related to the plasma nitrendipine concentration with r=-0.819. Clinically the maximal effective time was 2-6 h. |
| |
| Keywords: | nituendipine hypertension pharmacokinetics |
| 本文献已被 CNKI 等数据库收录！ |
|
