Treatment of osteochondral injuries. Genetic engineering |
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Authors: | Martinek V Fu F H Lee C W Huard J |
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Institution: | Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA. |
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Abstract: | Articular cartilage injuries are commonly encountered problems in sports medicine and orthopaedics. The treatment of chondral and osteochondral lesions, which possess only a very limited potential for healing, still represents a great challenge to clinicians and to scientists. Experimental investigations reported over the last 20 years have shown that a variety of methods, including implantation of periosteum, perichondrium, artificial matrices, growth factors, and transplanted cells, can stimulate formation of new cartilage. Genetic engineering--a combination of gene transfer techniques and tissue engineering--will facilitate new approaches to the treatment of articular cartilage injuries. |
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