| 槐胺碱对皮肤移植大鼠T淋巴细胞的影响 |
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| 引用本文： | 张佩,纪丽丽,王晨光,李淑华. 槐胺碱对皮肤移植大鼠T淋巴细胞的影响[J]. 中草药, 2001, 32(3): 230-232 |
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| 作者姓名： | 张佩 纪丽丽 王晨光 李淑华 |
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| 作者单位： | 1. 锦州医学院免疫微生物学教研室，辽宁锦州 121001
2. 锦州市妇婴医院病理科，辽宁锦州 121004 |
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| 摘 要： | 目的：研究槐胺碱（SA）对移植排斥反应的影响并探讨其发生机制。方法：以同种皮肤移植大鼠作为动物模型，免疫荧光浊测定T淋巴细胞及克亚群数量；MTT比色法测定T淋巴细胞增殖反应。结果：SA减少CD3、CD4细胞数、降低CD4／CD8，抑制T淋巴细胞的增殖，延长移植物存活时间。结论SA对移植排斥反应有抑制作用，此作用与其减少T淋巴细胞数量并抑制T淋巴细胞功能有关。
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| 关 键 词： | 槐胺碱 皮肤移植 T淋巴细胞 大鼠 移植排斥反应 |
| 文章编号： | 0253-2670(2001)03-0230-03 |
| 收稿时间： | 2000-06-12 |
| 修稿时间： | 2000-06-12 |
Effect of sophoramine on Tlymphocytes in rats of skin allograf ting |
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| ZHANG Pei,JI Li li,WANG Chen guang and LI Shu hua. Effect of sophoramine on Tlymphocytes in rats of skin allograf ting[J]. Chinese Traditional and Herbal Drugs, 2001, 32(3): 230-232 |
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| Authors: | ZHANG Pei JI Li li WANG Chen guang LI Shu hua |
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| Affiliation: | ZHANG Pei 1,JI Li li 2,WANG Chen guang 1,LI Shu hua 1 |
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| Abstract: | Object In order to obtain further evidence of therapeutic efficacy of sophoramine (SA) *, its effect on transplantation rejection was studied with simultaneous exploration of its mechanism of action Methods Number of T lymphocyte and its sub sets of skin allografted rat model were determined by immunofluorescence technique, and proliferation of T lymphocyte was assessed by thiazolyl blue (MTT) assay Results SA reduced the CD 3 and C 4 cell counts, lowered CD 4/C 8 ratio, inhibited T lymphocyte proliferation and prolonged the survival time of skin allografted rat Conclusion SA could inhibit transplantation rejection by inhibiting the function of T lymphocyte with simultaneous reduction of lymphocyte count |
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| Keywords: | sophoramine(SA) skin allografting T lymphocyte |
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