鲨鱼肝再生因子对大鼠慢性肝损伤的治疗作用

目的:探讨鲨鱼肝再生因子(sHRF)对大鼠慢性肝损伤的治疗作用。方法:CCl4致大鼠慢性肝损伤模型,给药后取血清及肝组织测定各项肝指标。结果:当用药8周时,对CCl4引起的肝损伤大鼠血清中AST、ALT活性的升高和羟脯氨酸含量的升高均有抑制作用,且0.8、1.6mg/kg剂量组的作用差异均有统计学意义。此外,sHRF能在一定程度上增加白蛋白含量,并使白蛋白/球蛋白比值有一定程度的升高。肝组织病理切片亦显示sHRF能减轻CCl4所致大鼠肝细胞脂肪变性及纤维组织增生。结论:sHRF对CCl4所致大鼠慢性肝损伤有一定的治疗作用。

Therapeutic effects of shark hepatic regenerative factor on chronic liver injury in rats

AIM:The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor(sHRF)on chronic liver injury in rats.METHODS:Chronic hepatic injury model in rats was induced by Carbon tetrachloride(CCl4).The activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS:Statistics indicated that chronic liver-injured rats with administration for 8 weeks,sHRF could suppress the elevation of ALT,AST in serum and Hydroxyproline in liver of liver injury rats induced by CCl4.There were no significant differences at the dosage of 0.8,1.6 mg/kg.Moreover,sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION:sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.