Synthesis and pharmacological properties of some derivatives of 3-phenylimidazo[4,5-b]pyridine |
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| Authors: | L Kaczmarek P Nantka-Namirski E Moryl E Chojnacka-Wójcik |
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| Affiliation: | Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa. |
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| Abstract: | The one-pot synthesis and properties of some derivatives of 3-phenylimidazo [4,5-b]pyridine (4a-g) were described. The central action of compounds 4a, 4f and 4g has been investigated using behavioral tests in mice and rats. The tested compounds showed a potent sedative effect. Compound 4f has central serotoninolytic properties in the m-CPP induced hyperthermia in rats. |
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