| 补益中药对老龄雄性大鼠下丘脑神经递质—性腺轴机能作用的研究 |
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| 引用本文： | 张新民,沈自尹,王文健,张玲娟,陈素珍.补益中药对老龄雄性大鼠下丘脑神经递质—性腺轴机能作用的研究[J].复旦学报(医学版),1991(5). |
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| 作者姓名： | 张新民 沈自尹 王文健 张玲娟 陈素珍 |
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| 作者单位： | 上海医科大学中西医结合研究所
(张新民，沈自尹，王文健，张玲娟)，上海医科大学中西医结合研究所(陈素珍) |
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| 摘 要： | 本文通过对3、18和24月龄雄性大鼠下丘脑NE、DA、5-HT、5-HIAA和下丘脑、垂体LRH;垂体、血LH;血E_2、T的测定,研究了老龄大鼠下丘脑神经递质及性腺轴机能的增龄性变化,并在此基础上探讨了补益中药对老龄大鼠下丘脑—垂体—性腺轴机能的作用。结果提示:老龄大鼠下丘脑机能的衰退可能是性腺轴机能衰退的主要原因;补益中药对老龄大鼠性腺轴机能的作用很可能是通过“改善”或“延缓”下丘脑或更高中枢调控机能的老年性变化来实现的。
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| 关 键 词： | 补益中药 下丘脑神经递质 性腺轴机能 延缓衰老 老年性变化 |
EFFECTS OF TONIFYING HERBS ON NEUROTRANSMITTERS AND HYPOTHALAMUS-PITUITARY-GONADAL AXIS IN AGED MALE RATS |
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| Zhang Xinmin,Shen Ziyin,Wang Wenjian,Zhang Linjuan,Chen Suzhen.EFFECTS OF TONIFYING HERBS ON NEUROTRANSMITTERS AND HYPOTHALAMUS-PITUITARY-GONADAL AXIS IN AGED MALE RATS[J].Fudan University Journal of Medical Sciences,1991(5). |
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| Authors: | Zhang Xinmin Shen Ziyin Wang Wenjian Zhang Linjuan Chen Suzhen |
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| Abstract: | Hypotnalamic norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindole-3-aoid (5-HIAA); hypothalamic and pituitary luteini-zing hormone-releasing hormone (LRH); pituitary and serum luteinzing hormone (LH); serum testosterone (T), estradiol (E2) were measured in 3-months, 18-months and 24-months old male rats. The eflFeots of tonifying herbs on the function of hypothalamus-pituitary-gonadal axis in aged male rats was also studied. Kesults showed that the decline of hypothalamus function in aging male rats might be the main cause of the aging change of gonadal function and the tonifying herbs could improve the function and they may be able to delay occurence of aging changes in the hypothalamus or the higher central regulation control. |
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| Keywords: | tonifying herbs hypothalamic neurotransmitter gonadal axis function aging change delaying aging |
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