| p14ARF在宫颈癌中的表达及其与p53表达相关性的研究 |
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| 引用本文： | 何培芝,刘少扬,江大琼.p14ARF在宫颈癌中的表达及其与p53表达相关性的研究[J].肿瘤防治研究,2005,32(1):27-29,F002. |
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| 作者姓名： | 何培芝 刘少扬 江大琼 |
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| 作者单位： | 430071,武汉大学附属中南医院妇瘤科 |
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| 摘 要： | 目的探讨宫颈癌组织p14ARF蛋白的表达及其与p53表达的相关性.方法应用免疫组化方法检测p14ARF、p53基因在41例宫颈癌及20例正常宫颈组织中的表达.结果p14ARF在正常宫颈组织中不表达,41例宫颈癌中35例表达阳性,占85.4%.病理分级为G1、G2级的宫颈癌的p4ARF阳性表达率为68.4%,G3级为100%,两者比较,有显著性差异(P＜0.05).宫颈癌组织中p53蛋白表达阳、阴性者中p14ARF蛋白表达阳性率分别为75.0%(12/16)和92.0%(23/25),两者比较,无显著性差异,p14ARF与p53表达不相关.结论p14ARF在宫颈癌中高表达有一定的诊断和估测预后价值,可能是宫颈癌新的肿瘤标志物.
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| 关 键 词： | 宫颈肿瘤 免疫组织化学 |
| 文章编号： | 1000-8578(2005)01-0027-03 |
Expression of p14ARF and p53 Protein in Cervical Carcinomas |
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| HE Pei-zhi,LIU Shao-yang,JIANG Da-qiong.Expression of p14ARF and p53 Protein in Cervical Carcinomas[J].Cancer Research on Prevention and Treatment,2005,32(1):27-29,F002. |
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| Authors: | HE Pei-zhi LIU Shao-yang JIANG Da-qiong |
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| Institution: | HE Pei-zhi,LIU Shao-yang,JIANG Da-qiong Department of Gynecologic Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | Objective To study the expression of p14~ARF protein in cervical carcinoma and its relationship with the expression of p53 gene. Methods The expression of p14~ARF and p53 protein was detected by immunohistochemistry in 41 cervical carcinoma tissues and 20 normal cervical tissues. Results p14~ARF was expressed in 35 of 41(~85.4% ) cases of cervical carcinomas.In contrast,normal cervical epithelium did not express p14~ARF .Overexpression of p14~ARF was related to the tumor grade.The expression of p14~ARF had no association with p53. Conclusion The overexpression of p14~ARF has value in diagnostic and prognosis in cervical neoplasm.These proteins maybe use as new markers of cervical neoplasm. |
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| Keywords: | p14ARF p53 |
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