HEPATITIS B AND C VIRUSES AND THEIR INTERACTION IN THE PTHOGENESIS OF HEPATOCELLULAR CARCINOMA

王树林，张耀铮ＨＥＰＡＴＩＴＩＳＢＡＮＤＣＶＩＲＵＳＥＳＡＮＤＴＨＥＩＲＩＮＴＥＲＡＣＴＩＯＮＩＮＴＨＥＰＴＨＯＧＥＮＥＳＩＳＯＦＨＥＰＡＴＯＣＥＬＬＵＬＡＲＣＡＲＣＩＮＯＭＡ￥ＷａｎｇＳｈｕｌｉｎ；ＺｈａｎｇＹａｏｚｈｅｎｇ；（Ｄｅｐａｒｔｍｅｎｔ...

Hepatitis B and C viruses and their interaction in the pthogenesis of hepatocellular carcinoma

The prevelence of hepatitis B and C virus (HBV and HCV) infections was studied in 46 patients with hepatocellular carcinoma (HCC) and 30 controls without liver disease. In addition to viral serological markers, Serum hepatitis B virus DNA and hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. The positive rates of HBV-DNA and HBV serological markers were 69.5% and 76.1% respectively,significantly higher than that in controls (16.7%and 16.7%, P<0.01); 14 patients (30.4%) were HCV-RNA positive, and 12 patients were Anti-HCV positive,remarkablely higher than that in controls, too. (6.7%and 6.7% respectively, P<0.05). Scrum HBV-DNA were all positive in HCC patients with serum HBeAg and/or HBcAb positive. Among HCC, 20% of HBV seronegative cases had HBV-DNA detectable in their serum.Coinfection by the two viruses was detected in seven suhjects (15.2%), but no clinical differences were found bet ween these and the rest of patients. We concluded that nearly 95.6.% (44 of 46 patients studied) of cases of HCC in our geographical area are related to hepatitis infections.Hepatitis B virus is more prevelent than hepatitis C virus in patients with HCC, and the infection is still active when the tumor is diagnosed. This fact is probably important in the contribution of hepatitis B and C virus infections to the development of hepatocellualr carcinoma.