妇科恶性肿瘤患者DNA倍体分析及其临床意义

目的探讨DNA倍体分析对妇科恶性肿瘤的应用价值。方法应用流式细胞术(FCM)测定78例妇科恶性肿瘤患者癌细胞DNA含量,并对DNA倍体和细胞周期各时相比例进行分析。结果妇科恶性肿瘤患者异倍体率和S期增高率分别为50.0%、42.3%,并且50岁以上患者明显高于50岁以下者,有明显差异(P<0.01);腺癌明显高于鳞癌(P<0.05);卵巢癌异倍体率及S期异常率最高,而宫颈癌最低;随病理分级的增高,异倍体率及S期异常率也呈增高的趋势。结论妇科恶性肿瘤患者DNA倍体的分析,可以有效地了解肿瘤细胞的增殖情况及恶变程度,从而指导治疗、改善预后。

Clinical Value and Analysis of DNA Ploid in Gynecology Tumor Sufferers

Objective To discuss the clinical value of DNA ploid in gynecology tumor patients. Methods By FCM technique, we examined the content of DNA ploid in tumor cell in 78 gynecology tumor patients, and analyzed the proportion of each period in one cell cycle. Results Within gynecology tumor patients, the rate of exceptional content of DNA is 50.0%, the rate of heighten S period is 42.3%. The rate of the patients over 50 years is much higher (P<0.01), and adenocarcinoma higher than squamous carcinoma (P<0.05). The rate of carcinoma ovarii is the highest in three kinds of gynecology tumors. Along with the increase of pathobiology grade, the rate also displayed the ascending direction. Conclusion The analysis of DNA ploid in gynecology tumor patients can availably realize the instance of the cell multiplication and the degree of cancerous. It can be used in instructed the project of therapy and improving prognosis.