Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid |
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Authors: | Greco R Latini G Chiarelli F Iannetti P Verrotti A |
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Institution: | Department of Medicine, University of Chieti, Italy. |
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Abstract: | The authors studied 40 epileptic patients treated with valproate and 40 healthy controls for at least 2 years. At the end of follow-up, 15 epileptic patients (37.5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight. |
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