近视患者中央角膜厚度的相关因素研究

目的:探讨影响近视患者中央角膜厚度(central corneal thickness,CCT)的因素。方法:本文所研究的近视及近视散光患者共307例614眼,用全自动电脑验光仪、角膜厚度测量仪、非接触式眼压计、A超、Orb-scan分别测量屈光状态、CCT,眼压(intraocular pressure,IOP)、眼轴(axial length,AL)、前房深度(anterior chamber depth,ACD)以及角膜曲率(corneal curvature,CC)。用Pearson相关分析及一元线性回归方法统计评估CCT与眼部参数的关系。结果:CCT平均值为542.30±33.52μm。Pearson相关分析显示CCT与IOP呈显著正相关(r=0.303,P=0.000),与平均CC呈显著负相关(r=-0.129,P=0.001),而与年龄(r=-0.050,P=0.213)、屈光度(r=0.024,P=0.561)、AL(r=0.061,P=0.131)、ACD(r=-0.031,P=0.445)等因素无关。结论:近视患者CCT与IOP及平均CC有相关性,CCT每增加100μm,IOP升高2.4mmHg。

Study on factors related to central corneal thickness in patients with myopia

AIM:To determine the factors related to central corneal thickness(CCT) in patients with myopia.METHODS:A total of 307 patients(614 eyes) of myopia or myopia astigmatism subjects were examined.Refraction was measured by CANON RK-F1 automatic-refractor.CCT was measured by Pachymeter SP 3000.Axial Length was measured by A-mode ultrasound(OPTIKON 2000).Intraocular pressure(IOP) was measured by CANON TX-F non-contact tonometer.Corneal curvature was measured by Orbscan II(BAUSCH& LOMB).Age was also analyzed.The relationships between CCT and other parameters were tested by Pearson’s correlation and linear regression analysis.RESULTS:The average CCT was 542.30±33.52μm.CCT was positively correlated with IOP(r=0.303,P=0.000),negatively correlated with average corneal curvature(r=-0.129,P=0.001).There were no significant correlations between the CCT and age(r=-0.050,P=0.213),refractive error(r=0.024,P=0.561),axial length(r=0.061,P=0.131) and anterior chamber depth(r=-0.031,P=0.445).CONCLUSION:The CCT was correlated with IOP and average corneal curvature in patients of myopia.If the average CCT increases 100μm,the IOP would increase 2.4mmHg.