葛根素治疗糖尿病性视网膜病变的超声评价

目的：研究彩色多普勒超声评价葛根素在治疗糖尿病视网膜病变（diabetic retinopathy,DR）中的治疗作用。方法：对87例糖尿病视网膜患者采用9g/L250mL生理盐水＋葛根素400mg静脉注射治疗,1次/d,15d为1疗程,应用GE公司LOGIQ7彩色多普勒超声诊断仪由同一人行视网膜血流探测检查。结果：患者87例一个疗程治疗后,临床症状改善者37例（43%）,视网膜中央动脉（CRA）血流参数明显变化者76例（87%）;CRA的血流参数是评价葛根素注射液治疗DR疗效的客观指标。结论：研究证明彩色多普勒超声能动态实时地观察视网膜中央动脉的各血流参数,可反映视网膜病变情况,对早期诊断DR病变,以及治疗及预后评估有重要意义。葛根素能显著改善微血管病变、微血栓患者供血,降低血糖、血脂、抗氧化、增加血液流动性,具有治疗糖尿病性周围神经病变以及改善胰岛素抵抗等作用。CRA的血流参数是评价葛根素注射液治疗DR疗效的客观指标。

Clinical effects of the puerarin on diabetic retinopathy by the ultrasound

AIM:To study the color Doppler ultrasound evaluation of the therapeutic effect of puerarin in the treatment of diabetic retinopathy (DR). METHODS:Totally 87 patients with DR were treated with normal saline 9g/L 250mL and puerarin 400mg intravenous injection, once a day, 15 days for a course. The application of GE’s longle 9 color Doppler ultrasonography by the same line of retinal blood flow probe inspection. RESULTS:Almost 37 cases (43%) of 87 cases were improved in clinical symptoms, and 76 cases (87%) were changed significantly in CRA flow parameters after a course of treatment . CONCLUSION:The dynamic real-time color Doppler ultrasound displays the central retinal artery blood flow parameters and the retinal lesions. It is important to evaluate the situation of the early diagnosis of DR lesions, clinical testing , treatment and prognosis. Puerarin can significantly improve microvascular disease, patients with micro blood clots, lower blood sugar, blood lipids, anti-oxidation, increase blood flow and treat diabetic peripheral neuropathy, insulin resistance and so on. CRA blood flow parameters are the objective indicators DR of evaluating the efficacy of puerarin injection.