Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,;Jining Medical College, Shandong Institute for Behavioral Medicine
Abstract:
BackgroundPresently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists.ObjectiveTo study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period, and to try to find out a method which can quantitatively evaluate learning ability.DesignCase observation, and correlation analysis.SettingsShandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College.ParticipantsTotally 70 patients with cerebral infarction admitted to Department of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3)years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives.MethodsWhen the patients were at convalescent period, their learning and memory ability were measured with “clinic memory scale (set A)”. The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale, temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis.Main outcome measuresCorrelation of rCBF in different brain regions and learning memory ability in patients with cerebral infarction.Results
