Increased CSF tau protein in corticobasal degeneration |
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| Authors: | Kazuko Mitani Yoshiko Furiya Toshiki Uchihara Kazuhiro Ishii Hiroshi Yamanouchi Hidehiro Mizusawa Hiroshi Mori |
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| Affiliation: | (1) Department of Neurology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173 Japan, JP;(2) Department of Molecular Biology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo, 168 Japan, JP;(3) Department of Neurology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113 Japan, JP;(4) Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashi-dai, Fuchu, Tokyo, 183 Japan Tel.: +81 423 25 3881, Fax: +81 423 21 8678, e-mail: uchihara@tmin.ac.jp, JP |
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| Abstract: | Using a sensitive sandwich enzyme-linked immunosorbent assay (ELISA) method, we measured the concentration of total tau protein in the cerebrospinal fluid (CSF) from nine patients with corticobasal degeneration (CBD) in comparison with 12 normal control subjects in order to assess its diagnostic value. The CSF concentration of tau in patients with CBD (0.69, 0.20 ng/ml: mean, SD) was higher than that in the normal controls (0.48, 0.14 ng/ml, P = 0.0076 unpaired t test). This increase in CBD patients may reflect widespread tau pathology in CBD, but should be interpreted with reserve as an aid to diagnosis. Received: 30 June 1997 Received in revised form: 1 September 1997 Accepted: 7 September 1997 |
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| Keywords: | Tau Corticobasal degeneration Cerebrospinal fluid Sandwich ELISA |
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