| BCR／ABLDCDF—FISH信号特征与染色体核型的关系及其在慢性粒细胞白血病中的意义 |
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| 引用本文： | 杜庆华,应逸,陈晓燕.BCR／ABLDCDF—FISH信号特征与染色体核型的关系及其在慢性粒细胞白血病中的意义[J].中国临床实用医学,2010,4(8):60-61. |
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| 作者姓名： | 杜庆华 应逸 陈晓燕 |
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| 作者单位： | 广州市第一人民医院血液科,510180 |
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| 摘 要： | 目的探讨慢性粒细胞白血病（CML）BCR／ABL DCCF—FISH的信号特点及其与染色体核型的关系。结果使用BCR／ABL的DCDF探针对65例慢性粒细胞白血病骨髓标本进行荧光原位杂交及染色体核型检查。结果65例CML核型43例Ph阳性，1例阴性，其余21例未行核性检查或无可分析分裂相；FISH结果65例均为BCR／ABL阳性，其中9例伴ASS基因缺失，5例复杂易位，1例＋Ph伴ASS基因缺失。结论传统核型与DCDF-FISH，应互相结合，方可对遗传学特征作出更准确分析。
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| 关 键 词： | 慢性粒细胞白血病 Ph染色体 DCDF—FISH BCR／ABL |
Significance of BCR/ABL DCDF-FISH signal pattern and karyotype in chronic myeloid leukemia |
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| DU Qing-hua,YING Yi,CHEN Xiao-yan.Significance of BCR/ABL DCDF-FISH signal pattern and karyotype in chronic myeloid leukemia[J].China Clinical Practical Medicine,2010,4(8):60-61. |
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| Authors: | DU Qing-hua YING Yi CHEN Xiao-yan |
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| Institution: | .( Department of Hematology, the First People＇ s Hospital of Guangzhou, Guangdong 510180, China ) |
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| Abstract: | Objective To investigate the relation between the BCR/ABL DCDF-FISH signal pattern and karyotype in chronic myeloid leukemia(CML). Methods 65 cases of CML were performed FISH and karyotyping. Results In 65 cases CML. 43 cases were Ph positive, 1 case was Ph negative, 21 cases had no performed karyotyping analysis. All of 65 cases were FISH positive,9 cases with ASS gene deletion, 5 cases with complex variant translocation, 1 case with (+) Ph and ASS gene deletion. Conclusion More precise analysis can be got by combining the result of FISH and karyotyping. |
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| Keywords: | DCDF-FISH BCR/ABL |
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