| CD56在急性髓系白血病细胞上的表达及微小残留病分析 |
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| 引用本文： | 干灵红,陈葆国,颜荣文,李伯利,罗文达.CD56在急性髓系白血病细胞上的表达及微小残留病分析[J].上海医学检验杂志,2010(5). |
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| 作者姓名： | 干灵红 陈葆国 颜荣文 李伯利 罗文达 |
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| 作者单位： | 浙江省台州医院中心实验室;浙江省台州医院血液科; |
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| 摘 要： | 目的探讨CD56在非M3急性髓系白血病(AML)中的表达及在微小残留病(MRD)检测的意义。方法应用流式细胞术分析145例非AML-M3 AML患者免疫表型,以CD56、CD19、CD117、CD34、CD33为标志,CD45设门MRD分析。结果 145例AML患者中CD56阳性37例,占25.52%,CD19阳性17例,占11.72%,分布在M1、M2、M4、M5。CD56或/和CD19阳性的AML患者共49例,其中CD56和CD19同时阳性5例,均为M2亚型。P170蛋白阳性36例,占24.83%,其表达率与CD56呈显著正相关(P<0.01)。48例AML患者在诱导治疗结束和维持治疗第14、32、56周作MRD检测。单纯CD56+组MRD阳性率93.55%,复发率77.41%,与单纯CD19+组(MRD阳性率25.00%,复发率0)比较,差异有统计学意义(P均<0.01)。CD56+CD19+组MRD阳性率100.00%,复发率80.00%,与单纯CD56+组比较,差异无统计学意义(P>0.05),与单纯CD19+组比较,差异有统计学意义(P<0.01)。结论 CD56、CD19在非M3 AML有较高的...
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| 关 键 词： | CD56 急性白血病 微小残留病 流式细胞术 |
Expression of CD56 in the cells of acute myeloid leukemia and its clinical significance in minimal residual disease |
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| GAN Linghong,CHEN Baoguo,YAN Rongwen,LI Boli,LUO Wenda..Expression of CD56 in the cells of acute myeloid leukemia and its clinical significance in minimal residual disease[J].Shanghai Journal of Medical Laboratory Sciences,2010(5). |
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| Authors: | GAN Linghong CHEN Baoguo YAN Rongwen LI Boli LUO Wenda |
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| Institution: | GAN Linghong1,CHEN Baoguo1,YAN Rongwen1,LI Boli1,LUO Wenda2.(1.Central Laboratory,Taizhou Hospital of Zhejiang Province,Zhejiang Linhai 317000,China,2.Department of Hematology,China) |
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| Abstract: | Objective To investigate the expression of CD56 in non-M3 acute myeloid leukemia(AML) and its clinical significance in the determination of minimal residual disease(MRD).Methods The immunophenotype of 145 patients with non AML-M3 AML was analyzed by flow cytometry as the markers of CD56,CD19,CD117,CD34 and CD33.MRD analysis was gated by CD45.Results CD56 and CD19 expressions were detected in 25.52%(37/145) and 11.72%(17/145) in patients with AML-M1,M2,M4 and M5,respectively.The data showed that 49 patients ... |
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| Keywords: | CD56 Acute myeloid leukemia Minimal residual disease Flow cytometry |
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