妊娠期肝内胆汁淤积症和新生儿凝血功能、肝功能影响的关系

目的：探讨妊娠期肝内胆汁淤积症（ICP）和新生儿肝功能、凝血功能的关系。方法：检测58例ICP孕妇和42例正常孕妇血甘胆酸、持续时间及其所生的新生儿肝功能和凝血功能，并进行比较和统计学分析。结果：①产前甘胆酸水平与新生儿肝功能、凝血功能呈正相关，有统计学意义（P〈0．001）；②高甘胆酸血症孕妇所生的新生儿肝功能和凝血功能与对照组比较，有显著性差异（P〈0．01）；③孕妇高甘胆酸持续时间与新生儿肝功能、凝血功能损害的关系，经统计学分析，没有显著性差异（P〉0．05）。结论：①孕妇高甘胆酸血症会造成新生儿肝功能、凝血功能的损害；②孕妇高甘胆酸持续的时间与新生儿肝功能、凝血功能损害不相关。

Relationship between intrahepatic cholestasis of pregnancy and neonates' hepatic and coagulate functions

Objective To study the relationship between intrahepatic cholestasis of pregnancy(ICP) and neonates' hepatic and coagulate functions.Methods The subjects included 58 pregnant women with ICP and their newborns,42 healthy pregnant women and their newborns as controls.The levels of cholyglycine(CG),lasting time of CG in maternal serum and fetal hepatic and coagulate functions were determined.Results First, a positive correlation in CG levels of maternal serum and fetal hepatic and coagulate functions existed(P<0.001).Second,the hepatic and coagulate functions of neonates born by pregnant women with ICP were significantly higher than those of controls(P<0.001).Third,there were no difference between lasting time of high CG in maternal serum and the lesion of fetal hepatic and coagulate functions.Conclusions The high concentration of CG in ICP could cause the lesion of hepatic and coagulate functions in their fetus.