Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding |
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| Authors: | H J Sch?n K Kremser C Prager R Kramar |
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| Affiliation: | Department of Medical Chemistry, University of Vienna, Austria. |
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| Abstract: | After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate. |
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