The synthesis of potential 5-lipoxygenase inhibitors. 1

A Synthetic Route to Potential Inhibitors of 5-Lipoxygenase, I Derivatives of enamino;(cyano)pyrrol are able to inhibit 5-lipoxygenase. Bulky substituents at position 2 of an aromatic moiety seem to increase the inhibitory potency. As a model compound, a 2,4-dinitrophenyl derivative was synthesized, and a new synthetic route was developed for enaminopyrrols with sterically demanding substituents.